[HTML][HTML] Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes
Fibroblast growth factor 21 (FGF21) is a liver-secreted endocrine factor with multiple
beneficial effects on obesity-related disorders. It enhances glucose uptake by inducing the
expression of glucose transporter-1 (GLUT1) in adipocytes. Here we investigated the
signaling pathways that mediate FGF21-induced GLUT1 expression and glucose uptake in
vitro and in animals. Quantitative real-time PCR and a luciferase reporter assay showed that
FGF21 induced GLUT1 expression through transcriptional activation. The truncation of the …
beneficial effects on obesity-related disorders. It enhances glucose uptake by inducing the
expression of glucose transporter-1 (GLUT1) in adipocytes. Here we investigated the
signaling pathways that mediate FGF21-induced GLUT1 expression and glucose uptake in
vitro and in animals. Quantitative real-time PCR and a luciferase reporter assay showed that
FGF21 induced GLUT1 expression through transcriptional activation. The truncation of the …