[HTML][HTML] Cleavage of amyloid-β precursor protein and amyloid-β precursor-like protein by BACE 1
Q Li, TC Südhof - Journal of Biological Chemistry, 2004 - ASBMB
Site-specific proteolysis of the amyloid-β precursor protein (APP) by BACE 1 and γ-
secretase, a central event in Alzheimer disease, releases a large secreted extracellular
fragment (called APP S), peptides of 40-43 residues derived from extracellular and
transmembrane sequences (Aβ), and a short intracellular fragment (APP intracellular
domain) that may function as a transcriptional activator in a complex with the adaptor protein
Fe65 and the nuclear protein Tip60. APP is closely related to APP-like protein (APLP) 1 and …
secretase, a central event in Alzheimer disease, releases a large secreted extracellular
fragment (called APP S), peptides of 40-43 residues derived from extracellular and
transmembrane sequences (Aβ), and a short intracellular fragment (APP intracellular
domain) that may function as a transcriptional activator in a complex with the adaptor protein
Fe65 and the nuclear protein Tip60. APP is closely related to APP-like protein (APLP) 1 and …