[HTML][HTML] Glycogen synthase kinase 3β induces caspase-cleaved tau aggregation in situ
JH Cho, GVW Johnson - Journal of Biological Chemistry, 2004 - ASBMB
Tau is a substrate of caspases, and caspase-cleaved tau has been detected in Alzheimer's
disease brain but not in control brain. Furthermore, in vitro studies have revealed that
caspase-cleaved tau is more fibrillogenic than full-length tau. Considering these previous
findings, the purpose of this study was to determine how the caspase cleavage of tau
affected tau function and aggregation in a cell model system. The effects of glycogen
synthase kinase 3β (GSK3β), a well established tau kinase, on these processes also were …
disease brain but not in control brain. Furthermore, in vitro studies have revealed that
caspase-cleaved tau is more fibrillogenic than full-length tau. Considering these previous
findings, the purpose of this study was to determine how the caspase cleavage of tau
affected tau function and aggregation in a cell model system. The effects of glycogen
synthase kinase 3β (GSK3β), a well established tau kinase, on these processes also were …