[HTML][HTML] Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP transgenic mice
L McConlogue, M Buttini, JP Anderson… - Journal of Biological …, 2007 - ASBMB
The aspartyl protease β-site amyloid precursor protein cleaving enzyme 1 (BACE1) initiates
processing of amyloid precursor protein (APP) into amyloid β (Aβ) peptide, the major
component of Alzheimer disease (AD) plaques. To determine the role that BACE1 plays in
the development of Aβ-driven AD-like pathology, we have crossed PDAPP mice, a
transgenic mouse model of AD overexpressing human mutated APP, onto mice with either a
homozygous or heterozygous BACE1 gene knockout. Analysis of PDAPP/BACE (-/-) mice …
processing of amyloid precursor protein (APP) into amyloid β (Aβ) peptide, the major
component of Alzheimer disease (AD) plaques. To determine the role that BACE1 plays in
the development of Aβ-driven AD-like pathology, we have crossed PDAPP mice, a
transgenic mouse model of AD overexpressing human mutated APP, onto mice with either a
homozygous or heterozygous BACE1 gene knockout. Analysis of PDAPP/BACE (-/-) mice …