ASP1 (BACE2) cleaves the amyloid precursor protein at the β-secretase site
I Hussain, DJ Powell, DR Howlett, GA Chapman… - Molecular and Cellular …, 2000 - Elsevier
Sequential proteolytic processing of the Amyloid Precursor Protein (APP) by β-and γ-
secretases generates the 4-kDa amyloid (Aβ) peptide, a key component of the amyloid
plaques seen in Alzheimer's disease (AD). We and others have recently reported the
identification and characterisation of an aspartic proteinase, Asp2 (BACE), as β-secretase.
Here we describe the characterization of a second highly related aspartic proteinase, Asp1
as a second β-secretase candidate. Asp1 is expressed in brain as detected at the mRNA …
secretases generates the 4-kDa amyloid (Aβ) peptide, a key component of the amyloid
plaques seen in Alzheimer's disease (AD). We and others have recently reported the
identification and characterisation of an aspartic proteinase, Asp2 (BACE), as β-secretase.
Here we describe the characterization of a second highly related aspartic proteinase, Asp1
as a second β-secretase candidate. Asp1 is expressed in brain as detected at the mRNA …