[HTML][HTML] The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1
SF Lichtenthaler, D Dominguez, GG Westmeyer… - Journal of Biological …, 2003 - ASBMB
The aspartyl protease BACE1 cleaves the amyloid precursor protein and the
sialyltransferase ST6Gal I and is important in the pathogenesis of Alzheimer's disease. The
normal function of BACE1 and additional physiological substrates have not been identified.
Here we show that BACE1 acts on the P-selectin glycoprotein ligand 1 (PSGL-1), which
mediates leukocyte adhesion in inflammatory reactions. In human monocytic U937 and
human embryonic kidney 293 cells expressing endogenous or transfected BACE1, PSGL-1 …
sialyltransferase ST6Gal I and is important in the pathogenesis of Alzheimer's disease. The
normal function of BACE1 and additional physiological substrates have not been identified.
Here we show that BACE1 acts on the P-selectin glycoprotein ligand 1 (PSGL-1), which
mediates leukocyte adhesion in inflammatory reactions. In human monocytic U937 and
human embryonic kidney 293 cells expressing endogenous or transfected BACE1, PSGL-1 …