Encapsulated PC12 cell transplants into hemiparkinsonian monkeys: a behavioral, neuroanatomical, and neurochemical analysis
JH Kordower, YT Liu, S Winn, DF Emerich - Cell Transplantation, 1995 - Elsevier
Four cynomolgus monkeys were trained on a hand reaching task and then rendered
hemiparkinsonian with an intracarotid injection of n-methyl 4 phenyl 1, 2, 3, 6,
tetrahydropyridine (MPTP). Performance on this task with the limb contralateral to the MPTP
injection was significantly impaired following the lesion. Three monkeys received implants of
polymer-encapsulated containing PC12 cells into the caudate nucleus and putamen. One
monkey received identical implants of empty capsules and served as a control. After a …
hemiparkinsonian with an intracarotid injection of n-methyl 4 phenyl 1, 2, 3, 6,
tetrahydropyridine (MPTP). Performance on this task with the limb contralateral to the MPTP
injection was significantly impaired following the lesion. Three monkeys received implants of
polymer-encapsulated containing PC12 cells into the caudate nucleus and putamen. One
monkey received identical implants of empty capsules and served as a control. After a …