Molecular programming of stem cells into mesodiencephalic dopaminergic neurons
JPH Burbach, MP Smidt - Trends in neurosciences, 2006 - cell.com
JPH Burbach, MP Smidt
Trends in neurosciences, 2006•cell.comIn a screen for homeobox transcription factors expressed in the embryonic ventral midbrain,
Andersson et al. recently identified Lmx1a and Msx1. Using in ovo electroporation in chick
embryos, they showed that these factors are crucial for initiating the differentiation of
neuroepithelial progenitor neurons into mesodiencephalic dopaminergic (mdDA) neurons.
Lmx1a also initiated a developmental program that drove an mdDA phenotype in mouse
embryonic stem cells. This indicates that these factors can be exploited in cell-replacement …
Andersson et al. recently identified Lmx1a and Msx1. Using in ovo electroporation in chick
embryos, they showed that these factors are crucial for initiating the differentiation of
neuroepithelial progenitor neurons into mesodiencephalic dopaminergic (mdDA) neurons.
Lmx1a also initiated a developmental program that drove an mdDA phenotype in mouse
embryonic stem cells. This indicates that these factors can be exploited in cell-replacement …
In a screen for homeobox transcription factors expressed in the embryonic ventral midbrain, Andersson et al. recently identified Lmx1a and Msx1. Using in ovo electroporation in chick embryos, they showed that these factors are crucial for initiating the differentiation of neuroepithelial progenitor neurons into mesodiencephalic dopaminergic (mdDA) neurons. Lmx1a also initiated a developmental program that drove an mdDA phenotype in mouse embryonic stem cells. This indicates that these factors can be exploited in cell-replacement strategies for treatment of Parkinson's disease.
cell.com