Immunosuppressive HLA-G molecule is upregulated in alveolar epithelial cells after influenza A virus infection
F LeBouder, K Khoufache, C Menier, Y Mandouri… - Human immunology, 2009 - Elsevier
Influenza virus type A (IAV) infections constitute an important economic burden and raise
health-care problems. Host defense mechanisms usually clear IAV infections after a few
days by exploiting a variety of cellular immune responses. However, increasing the
production of immunosubversive molecules is a mechanism by which viruses escape host
surveillance. In this regard, the nonclassical HLA class I molecule HLA-G displays strong
tolerogenic properties. We show here that several strains of IAV differently upregulate HLA …
health-care problems. Host defense mechanisms usually clear IAV infections after a few
days by exploiting a variety of cellular immune responses. However, increasing the
production of immunosubversive molecules is a mechanism by which viruses escape host
surveillance. In this regard, the nonclassical HLA class I molecule HLA-G displays strong
tolerogenic properties. We show here that several strains of IAV differently upregulate HLA …