Renin-angiotensin-aldosterone system and progression of renal disease
C Rüster, G Wolf - Journal of the American Society of Nephrology, 2006 - journals.lww.com
Inhibition of the renin-angiotensin-aldosterone system (RAAS) is one of the most powerful
maneuvers to slow progression of renal disease. Angiotensin II (AngII) has emerged in the
past decade as a multifunctional cytokine that exhibits many nonhemodynamic properties,
such as acting as a growth factor and profibrogenic cytokine, and even having
proinflammatory properties. Many of these deleterious functions are mediated by other
factors, such as TGF-β and chemoattractants that are induced in the kidney by AngII …
maneuvers to slow progression of renal disease. Angiotensin II (AngII) has emerged in the
past decade as a multifunctional cytokine that exhibits many nonhemodynamic properties,
such as acting as a growth factor and profibrogenic cytokine, and even having
proinflammatory properties. Many of these deleterious functions are mediated by other
factors, such as TGF-β and chemoattractants that are induced in the kidney by AngII …