Association between angiotensin-converting enzyme gene polymorphisms and diabetic nephropathy: case-control, haplotype, and family-based study in three …
S Hadjadj, L Tarnow, C Forsblom… - Journal of the …, 2007 - journals.lww.com
Angiotensin 1-converting enzyme gene (ACE) is a risk factor for diabetic nephropathy (DN)
in patients with type 1 diabetes. The selection of this candidate gene is supported by cross-
sectional and follow-up studies, but no convincing family-based studies are available.
Recruited were 1057 patients (with DN: persistent albuminuria with or without renal failure)
and 1127 control subjects (long-standing [≥ 15 yr] normoalbuminuric patients with type 1
diabetes) in Denmark, Finland, and France and 532 family trios that were composed of 244 …
in patients with type 1 diabetes. The selection of this candidate gene is supported by cross-
sectional and follow-up studies, but no convincing family-based studies are available.
Recruited were 1057 patients (with DN: persistent albuminuria with or without renal failure)
and 1127 control subjects (long-standing [≥ 15 yr] normoalbuminuric patients with type 1
diabetes) in Denmark, Finland, and France and 532 family trios that were composed of 244 …