[18] Peptidyl dipeptidase A: Angiotensin I-converting enzyme
P Corvol, TA Williams, F Soubrier - Methods in enzymology, 1995 - Elsevier
Peptidyl dipeptidase A (EC 3.4. 15.1) is a Zn2+-metallopeptidase which acts on many
substrates, primarily by releasing a C-terminal dipeptide. Its broad substrate specificity
explains its successive denominations as angiotensin I-converting enzyme (ACE) since it
cleaves the C-terminal dipeptide from angiotensin I (AI) to produce the potent vasopressor
octapeptide angiotensin II, 1 and as kininase II because it inactivates bradykinin (BK)
substrates, primarily by releasing a C-terminal dipeptide. Its broad substrate specificity
explains its successive denominations as angiotensin I-converting enzyme (ACE) since it
cleaves the C-terminal dipeptide from angiotensin I (AI) to produce the potent vasopressor
octapeptide angiotensin II, 1 and as kininase II because it inactivates bradykinin (BK)