Nitric oxide red blood cell membrane permeability at high and low oxygen tension
KT Huang, Z Huang, DB Kim-Shapiro - Nitric Oxide, 2007 - Elsevier
Red blood cell (RBC) encapsulated hemoglobin in the blood scavenges nitric oxide (NO)
much more slowly than cell-free hemoglobin would. Part of this reduced NO scavenging has
been attributed to an intrinsic membrane barrier to diffusion of NO through the RBC
membrane. Published values for the permeability of RBCs to NO vary over several orders of
magnitude. Recently, the rate that RBCs scavenge NO has been shown to depend on the
hematocrit (percentage volume of RBCs) and oxygen tension. The difference in rate …
much more slowly than cell-free hemoglobin would. Part of this reduced NO scavenging has
been attributed to an intrinsic membrane barrier to diffusion of NO through the RBC
membrane. Published values for the permeability of RBCs to NO vary over several orders of
magnitude. Recently, the rate that RBCs scavenge NO has been shown to depend on the
hematocrit (percentage volume of RBCs) and oxygen tension. The difference in rate …