[HTML][HTML] Human carbonyl reductase 1 is an S-nitrosoglutathione reductase
RL Bateman, D Rauh, B Tavshanjian… - Journal of Biological …, 2008 - ASBMB
Human carbonyl reductase 1 (hCBR1) is an NADPH-dependent short chain
dehydrogenase/reductase with broad substrate specificity and is thought to be responsible
for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing
compounds including xenobiotics. In addition, hCBR1 possesses a glutathione binding site
that allows for increased affinity toward GSH-conjugated molecules. It has been suggested
that the GSH-binding site is near the active site; however, no structures with GSH or GSH …
dehydrogenase/reductase with broad substrate specificity and is thought to be responsible
for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing
compounds including xenobiotics. In addition, hCBR1 possesses a glutathione binding site
that allows for increased affinity toward GSH-conjugated molecules. It has been suggested
that the GSH-binding site is near the active site; however, no structures with GSH or GSH …