To be 17 again—Anti–interleukin-17 treatment for psoriasis

A Waisman - New England Journal of Medicine, 2012 - Mass Medical Soc
New England Journal of Medicine, 2012Mass Medical Soc
Interleukin-17 is a cytokine that belongs to a family of six members (interleukins 17A through
17F), which bind a total of five receptors (interleukins 17RA through 17RE). 1–3 Of these six
interleukin-17 cytokines, interleukins 17A and 17F are very homologous and bind the same
receptor complex (interleukins 17RA and 17RC). Interleukin-17A is the founding member of
the family and is therefore also termed interleukin-17.4 It was identified in 1993 as a cytokine
that mediates the production of chemokines and subsequently the recruitment of neutrophils …
Interleukin-17 is a cytokine that belongs to a family of six members (interleukins 17A through 17F), which bind a total of five receptors (interleukins 17RA through 17RE).13 Of these six interleukin-17 cytokines, interleukins 17A and 17F are very homologous and bind the same receptor complex (interleukins 17RA and 17RC). Interleukin-17A is the founding member of the family and is therefore also termed interleukin-17.4 It was identified in 1993 as a cytokine that mediates the production of chemokines and subsequently the recruitment of neutrophils to sites of inflammation.3 Although interleukin-17 has been discussed recently with reference to autoimmune diseases, one . . .
The New England Journal Of Medicine