[HTML][HTML] Cyclin D1 splice variants: differential effects on localization, RB phosphorylation, and cellular transformation
DA Solomon, Y Wang, SR Fox, TC Lambeck… - Journal of Biological …, 2003 - ASBMB
Cyclin D1 is a proto-oncogene that functions by inactivation of the retinoblastoma tumor
suppressor protein, RB. A common polymorphism in the cyclin D1 gene is associated with
the production of an alternate transcript of cyclin D1, termed cyclin D1b. Both the
polymorphism and the variant transcript are associated with increased risk for multiple
cancers and the severity of a given cancer; however, the underlying activities of cyclin D1b
have not been elucidated relative to the canonical cyclin D1a. Because cyclin D1b does not …
suppressor protein, RB. A common polymorphism in the cyclin D1 gene is associated with
the production of an alternate transcript of cyclin D1, termed cyclin D1b. Both the
polymorphism and the variant transcript are associated with increased risk for multiple
cancers and the severity of a given cancer; however, the underlying activities of cyclin D1b
have not been elucidated relative to the canonical cyclin D1a. Because cyclin D1b does not …