[HTML][HTML] Cyclin D1 is a selective modifier of androgen-dependent signaling and androgen receptor function

CES Comstock, MA Augello, MJ Schiewer… - Journal of biological …, 2011 - ASBMB
D-type cyclins regulate cellular outcomes in part through cyclin-dependent, kinase-
independent mechanisms that modify transcription factor action, and recent in vivo studies
showed that cyclin D1 associates with a large number of transcriptional regulators in cells of
the retina and breast. Given the frequency of cyclin D1 alterations in cancer, it is imperative
to delineate the molecular mechanisms by which cyclin D1 controls key transcription factor
networks in human disease. Prostate cancer was used as a paradigm because this tumor …