Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity
HE Liang, RL Reinhardt, JK Bando, BM Sullivan… - Nature …, 2012 - nature.com
HE Liang, RL Reinhardt, JK Bando, BM Sullivan, IC Ho, RM Locksley
Nature immunology, 2012•nature.comAbstract Interleukin 4 (IL-4) and IL-13 are critical for responses to parasitic helminthes. We
used genetically engineered reporter mice to assess the temporal and spatial production of
these cytokines in vivo. In lymph nodes, IL-4, but not IL-13, was made by follicular helper T
cells (TFH cells). In contrast, tissue type 2 helper T cells (TH2 cells) produced both cytokines.
There was also divergent production of IL-4 and IL-13 among cells of the innate immune
system, whereby basophils produced IL-4, whereas innate helper type 2 cells (Ih2 cells) …
used genetically engineered reporter mice to assess the temporal and spatial production of
these cytokines in vivo. In lymph nodes, IL-4, but not IL-13, was made by follicular helper T
cells (TFH cells). In contrast, tissue type 2 helper T cells (TH2 cells) produced both cytokines.
There was also divergent production of IL-4 and IL-13 among cells of the innate immune
system, whereby basophils produced IL-4, whereas innate helper type 2 cells (Ih2 cells) …
Abstract
Interleukin 4 (IL-4) and IL-13 are critical for responses to parasitic helminthes. We used genetically engineered reporter mice to assess the temporal and spatial production of these cytokines in vivo. In lymph nodes, IL-4, but not IL-13, was made by follicular helper T cells (TFH cells). In contrast, tissue type 2 helper T cells (TH2 cells) produced both cytokines. There was also divergent production of IL-4 and IL-13 among cells of the innate immune system, whereby basophils produced IL-4, whereas innate helper type 2 cells (Ih2 cells) produced IL-13. IL-13 production by TH2 and Ih2 cells was dependent on the transcription factor GATA-3, which was present in large amounts in these cells, and in contrast to the small amount of GATA-3 in TFH cells and basophils. The distinct localization and cellular expression of IL-4 and IL-13 explains their unique roles during allergic immunity.
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