The glucose-regulated proteins: stress induction and clinical applications
AS Lee - Trends in biochemical sciences, 2001 - cell.com
AS Lee
Trends in biochemical sciences, 2001•cell.comA protective mechanism used by cells to adapt to stress of the endoplasmic reticulum (ER) is
the induction of members of the glucose-regulated protein (Grp) family. The induction of
mammalian Grp proteins in response to ER stress involves a complex network of regulators
and novel mechanisms. The elucidation of Grp function and regulation opens up new
therapeutic approaches to diseases associated with ER stress and cancer.
the induction of members of the glucose-regulated protein (Grp) family. The induction of
mammalian Grp proteins in response to ER stress involves a complex network of regulators
and novel mechanisms. The elucidation of Grp function and regulation opens up new
therapeutic approaches to diseases associated with ER stress and cancer.
Abstract
A protective mechanism used by cells to adapt to stress of the endoplasmic reticulum (ER) is the induction of members of the glucose-regulated protein (Grp) family. The induction of mammalian Grp proteins in response to ER stress involves a complex network of regulators and novel mechanisms. The elucidation of Grp function and regulation opens up new therapeutic approaches to diseases associated with ER stress and cancer.
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