[HTML][HTML] Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1 (S)-induced endoplasmic reticulum biogenesis
R Sriburi, H Bommiasamy, GL Buldak… - Journal of Biological …, 2007 - ASBMB
Development of the expansive endoplasmic reticulum (ER) present in specialized secretory
cell types requires X-box-binding protein-1 (Xbp-1). Enforced expression of XBP-1 (S), a
transcriptional activator generated by unfolded protein response-mediated splicing of Xbp-1
mRNA, is sufficient to induce proliferation of rough ER. We previously showed that XBP-1 (S)-
induced ER biogenesis in fibroblasts correlates with increased production of
phosphatidylcholine (PtdCho), the primary phospholipid of the ER membrane, and …
cell types requires X-box-binding protein-1 (Xbp-1). Enforced expression of XBP-1 (S), a
transcriptional activator generated by unfolded protein response-mediated splicing of Xbp-1
mRNA, is sufficient to induce proliferation of rough ER. We previously showed that XBP-1 (S)-
induced ER biogenesis in fibroblasts correlates with increased production of
phosphatidylcholine (PtdCho), the primary phospholipid of the ER membrane, and …