[HTML][HTML] In vivo studies of Scn5a+/− mice modeling Brugada syndrome demonstrate both conduction and repolarization abnormalities

CA Martin, Y Zhang, AA Grace, CLH Huang - Journal of electrocardiology, 2010 - Elsevier
OBJECTIVES: We investigate the extent to which the electrocardiographic (ECG) properties
of intact Scn5a+/− mice reproduce the corresponding clinical Brugada syndrome phenotype
and use this model to investigate the role of conduction and repolarization abnormalities in
the arrhythmogenic mechanism. METHODS AND RESULTS: The ECGs were obtained from
anesthetized wild-type and Scn5a+/− mice, before and after administration of the known pro-
and antiarrhythmic agents flecainide and quinidine. The ECG intervals were measured and …