[HTML][HTML] Nox1 redox signaling mediates oncogenic Ras-induced disruption of stress fibers and focal adhesions by down-regulating Rho
M Shinohara, WH Shang, M Kubodera… - Journal of Biological …, 2007 - ASBMB
Generation of reactive oxygen species (ROS) by Ras oncogene-induced NADPH oxidase
(Nox) 1 is required for Ras transformation phenotypes including anchorage-independent
growth, morphological transformation, and tumorigenesity, but the signaling mechanism
downstream of Nox1 remains elusive. Rho is known to be a critical regulator of actin stress
fiber formation. Nonetheless, Rho was reported to no longer couple to loss of actin stress
fibers in Ras-transformed Swiss3T3 cells despite the elevation of Rho activity. In this study …
(Nox) 1 is required for Ras transformation phenotypes including anchorage-independent
growth, morphological transformation, and tumorigenesity, but the signaling mechanism
downstream of Nox1 remains elusive. Rho is known to be a critical regulator of actin stress
fiber formation. Nonetheless, Rho was reported to no longer couple to loss of actin stress
fibers in Ras-transformed Swiss3T3 cells despite the elevation of Rho activity. In this study …