Tbx18 and the fate of epicardial progenitors
VM Christoffels, T Grieskamp, J Norden… - Nature, 2009 - nature.com
VM Christoffels, T Grieskamp, J Norden, MTM Mommersteeg, C Rudat, A Kispert
Nature, 2009•nature.comAbstract Arising from: C.-L. Cai et al. Nature454, 104–108 (2008) 10.1038/nature06969; Cai
et al. reply Uncovering the origins of myocardial cells is important for understanding and
treating heart diseases,. Cai et al. suggest that Tbx18-expressing epicardium provides a
substantial contribution to myocytes in the ventricular septum and the atrial and ventricular
walls. Here we show that the T-box transcription factor gene 18 (Tbx18) itself is expressed in
the myocardium, showing that their genetic lineage tracing system does not allow …
et al. reply Uncovering the origins of myocardial cells is important for understanding and
treating heart diseases,. Cai et al. suggest that Tbx18-expressing epicardium provides a
substantial contribution to myocytes in the ventricular septum and the atrial and ventricular
walls. Here we show that the T-box transcription factor gene 18 (Tbx18) itself is expressed in
the myocardium, showing that their genetic lineage tracing system does not allow …
Abstract
Arising from: C.-L. Cai et al.Nature454, 104–108 (2008)10.1038/nature06969; Cai et al.reply
Uncovering the origins of myocardial cells is important for understanding and treating heart diseases,. Cai et al. suggest that Tbx18-expressing epicardium provides a substantial contribution to myocytes in the ventricular septum and the atrial and ventricular walls. Here we show that the T-box transcription factor gene 18 (Tbx18) itself is expressed in the myocardium, showing that their genetic lineage tracing system does not allow conclusions of an epicardial origin of cardiomyocytes in vivo to be drawn.
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