Metastamir: the field of metastasis-regulatory microRNA is spreading
Cancer research, 2009•AACR
Despite advancements in knowledge from more than a century of metastasis research, the
genetic programs and molecular mechanisms required for cancer metastasis are still
incompletely understood. Genes that specifically regulate the process of metastasis are
useful tools to elucidate molecular mechanisms and may become markers and/or targets for
antimetastatic therapy. Recently, several noncoding regulatory RNA genes, microRNA
(miRNA), were identified, which play roles in various steps of metastasis, some without …
genetic programs and molecular mechanisms required for cancer metastasis are still
incompletely understood. Genes that specifically regulate the process of metastasis are
useful tools to elucidate molecular mechanisms and may become markers and/or targets for
antimetastatic therapy. Recently, several noncoding regulatory RNA genes, microRNA
(miRNA), were identified, which play roles in various steps of metastasis, some without …
Abstract
Despite advancements in knowledge from more than a century of metastasis research, the genetic programs and molecular mechanisms required for cancer metastasis are still incompletely understood. Genes that specifically regulate the process of metastasis are useful tools to elucidate molecular mechanisms and may become markers and/or targets for antimetastatic therapy. Recently, several noncoding regulatory RNA genes, microRNA (miRNA), were identified, which play roles in various steps of metastasis, some without obvious roles in tumorigenesis. Understanding how these metastasis-associated miRNA, which we term metastamir, are involved in metastasis will help identify possible biomarkers or targets for the most lethal attribute of cancer: metastasis. [Cancer Res 2009;69(19):7495–8]
AACR