FunNet: an integrative tool for exploring transcriptional interactions

E Prifti, JD Zucker, K Clement, C Henegar - Bioinformatics, 2008 - academic.oup.com
Bioinformatics, 2008academic.oup.com
We describe here an exploratory tool, called FunNet, which implements an original systems
biology approach, aiming to improve the biological relevance of the modular interaction
patterns identified in transcriptional co-expression networks. A suitable analytical model,
involving two abstraction layers, has been devised to relate expression profiles to the
knowledge on transcripts' biological roles, extracted from genomic databases, into a
comprehensive exploratory framework. This approach has been implemented into a user …
Abstract
Summary: We describe here an exploratory tool, called FunNet, which implements an original systems biology approach, aiming to improve the biological relevance of the modular interaction patterns identified in transcriptional co-expression networks. A suitable analytical model, involving two abstraction layers, has been devised to relate expression profiles to the knowledge on transcripts’ biological roles, extracted from genomic databases, into a comprehensive exploratory framework. This approach has been implemented into a user-friendly web tool to promote its open use by the community.
Availability:  http://www.funnet.info
Contact:  edi.prifti@crc.jussieu.fr
Oxford University Press