[HTML][HTML] Genetic deletion of glycogen synthase kinase-3β abrogates activation of IκBα kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by …
Y Takada, X Fang, MS Jamaluddin, DD Boyd… - Journal of Biological …, 2004 - ASBMB
Glycogen synthase kinase (GSK)-3β is a constitutively active, proline-directed
serine/threonine kinase that controls growth modulation and tumorigenesis through multiple
intracellular signaling pathways. How GSK-3β regulates signaling pathways induced by
cytokines such as tumor necrosis factor (TNF) is poorly understood. In this study, we used
fibroblasts derived from GSK-3β gene-deleted mice to understand the role of this kinase in
TNF signaling. TNF induced NF-κB activation as measured by DNA binding in wild-type …
serine/threonine kinase that controls growth modulation and tumorigenesis through multiple
intracellular signaling pathways. How GSK-3β regulates signaling pathways induced by
cytokines such as tumor necrosis factor (TNF) is poorly understood. In this study, we used
fibroblasts derived from GSK-3β gene-deleted mice to understand the role of this kinase in
TNF signaling. TNF induced NF-κB activation as measured by DNA binding in wild-type …