[HTML][HTML] Differential regulation of STAT family members by glycogen synthase kinase-3
Excessive neuroinflammation contributes to many neurological disorders and is poorly
controlled therapeutically. The signal transducer and activator of transcription (STAT) family
of transcription factors has a central role in inflammatory reactions, being stimulated by
multiple cytokines and interferons and regulating the expression of many proteins involved
in inflammation. We found that STAT3 activation is highly dependent on glycogen synthase
kinase-3 (GSK3). Inhibitors of GSK3 greatly reduced (> 75%) the activating STAT3 tyrosine …
controlled therapeutically. The signal transducer and activator of transcription (STAT) family
of transcription factors has a central role in inflammatory reactions, being stimulated by
multiple cytokines and interferons and regulating the expression of many proteins involved
in inflammation. We found that STAT3 activation is highly dependent on glycogen synthase
kinase-3 (GSK3). Inhibitors of GSK3 greatly reduced (> 75%) the activating STAT3 tyrosine …