[HTML][HTML] Phosphorylation regulates intracellular trafficking of β-secretase
β-Secretase (BACE) is a transmembrane aspartyl protease, which generates the N terminus
of Alzheimer's disease amyloid β-peptide. Here, we report that BACE can be phosphorylated
within its cytoplasmic domain at serine residue 498 by casein kinase 1. Phosphorylation
exclusively occurs after full maturation of BACE by propeptide cleavage and complex N-
glycosylation. Phosphorylation/dephosphorylation affects the subcellular localization of
BACE. BACE wild type and an S498D mutant that mimics phosphorylated BACE are …
of Alzheimer's disease amyloid β-peptide. Here, we report that BACE can be phosphorylated
within its cytoplasmic domain at serine residue 498 by casein kinase 1. Phosphorylation
exclusively occurs after full maturation of BACE by propeptide cleavage and complex N-
glycosylation. Phosphorylation/dephosphorylation affects the subcellular localization of
BACE. BACE wild type and an S498D mutant that mimics phosphorylated BACE are …