Signaling Pathways Involved in Proteinase‐Activated Receptor1‐Induced Proinflammatory and Profibrotic Mediator Release Following Lung Injury
PF Mercer, X Deng… - Annals of the New York …, 2007 - Wiley Online Library
PF Mercer, X Deng, RC Chambers
Annals of the New York Academy of Sciences, 2007•Wiley Online LibraryThe proteinase‐activated receptors (PAR1 to 4) represent important novel therapeutic
targets in fibroproliferative lung disorders, linking signals from coagulation proteinases to the
production of proinflammatory and profibrotic mediators, in response to lung injury. This
review focuses on the current understanding of cytokine and chemokine release
downstream of PAR1 activation in the context of fibroproliferative lung disease, with an
emphasis on the induction of the chemokine CCL2/MCP‐1.
targets in fibroproliferative lung disorders, linking signals from coagulation proteinases to the
production of proinflammatory and profibrotic mediators, in response to lung injury. This
review focuses on the current understanding of cytokine and chemokine release
downstream of PAR1 activation in the context of fibroproliferative lung disease, with an
emphasis on the induction of the chemokine CCL2/MCP‐1.
Abstract
: The proteinase‐activated receptors (PAR1 to 4) represent important novel therapeutic targets in fibroproliferative lung disorders, linking signals from coagulation proteinases to the production of proinflammatory and profibrotic mediators, in response to lung injury. This review focuses on the current understanding of cytokine and chemokine release downstream of PAR1 activation in the context of fibroproliferative lung disease, with an emphasis on the induction of the chemokine CCL2/MCP‐1.
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