Losing balance: the origin and impact of aneuploidy in cancer: 'Exploring aneuploidy: the significance of chromosomal imbalance'review series

AJ Holland, DW Cleveland - EMBO reports, 2012 - embopress.org
EMBO reports, 2012embopress.org
Most solid human tumours are aneuploid, that is, they contain an abnormal number of
chromosomes. Paradoxically, however, aneuploidy has been reported to induce a stress
response that suppresses cellular proliferation in vitro. Here, we review the progress in our
understanding of the causes and effects of aneuploidy in cancer and discuss how, in specific
contexts, aneuploidy can provide a growth advantage and facilitate cellular transformation.
We also explore the emerging possibilities for targeting the cause or consequences of …
Most solid human tumours are aneuploid, that is, they contain an abnormal number of chromosomes. Paradoxically, however, aneuploidy has been reported to induce a stress response that suppresses cellular proliferation in vitro. Here, we review the progress in our understanding of the causes and effects of aneuploidy in cancer and discuss how, in specific contexts, aneuploidy can provide a growth advantage and facilitate cellular transformation. We also explore the emerging possibilities for targeting the cause or consequences of aneuploidy therapeutically.
embopress.org