p38 MAPK inhibitors, IKK2 inhibitors, and TNFα inhibitors in COPD
A Banerjee, C Koziol-White, R Panettieri Jr - Current Opinion in …, 2012 - Elsevier
COPD represents a major respiratory disorder, causing significant morbidity and mortality
throughout the world. While therapies exist for COPD, they are not always effective, and
many patients experience exacerbations and morbidity despite current therapies. Study of
the molecular mechanisms involved in the underlying physiological manifestations of COPD
has yielded multiple new targets for therapeutic intervention. In this review, we discuss
signaling pathways involved in COPD pathogenesis and review clinical studies of p38 …
throughout the world. While therapies exist for COPD, they are not always effective, and
many patients experience exacerbations and morbidity despite current therapies. Study of
the molecular mechanisms involved in the underlying physiological manifestations of COPD
has yielded multiple new targets for therapeutic intervention. In this review, we discuss
signaling pathways involved in COPD pathogenesis and review clinical studies of p38 …