[HTML][HTML] BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo

Y Kuma, G Sabio, J Bain, N Shpiro, R Márquez… - Journal of Biological …, 2005 - ASBMB
The compound BIRB796 inhibits the stress-activated protein kinases p38α and p38β and is
undergoing clinical trials for the treatment of inflammatory diseases. Here we report that
BIRB796 also inhibits the activity and the activation of SAPK3/p38γ. This occurs at higher
concentrations of BIRB796 than those that inhibit p38α and p38β and at lower
concentrations than those that inhibit the activation of JNK isoforms. We also show that at
these concentrations, BIRB796 blocks the stress-induced phosphorylation of the scaffold …