[HTML][HTML] Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability
T Murakami, EA Felinski, DA Antonetti - Journal of Biological Chemistry, 2009 - ASBMB
Vascular endothelial growth factor (VEGF) alters tight junctions (TJs) and promotes vascular
permeability in many retinal and brain diseases. However, the molecular mechanisms of
barrier regulation are poorly understood. Here we demonstrate that occludin
phosphorylation and ubiquitination regulate VEGF-induced TJ protein trafficking and
concomitant vascular permeability. VEGF treatment induced TJ fragmentation and occludin
trafficking from the cell border to early and late endosomes, concomitant with increased …
permeability in many retinal and brain diseases. However, the molecular mechanisms of
barrier regulation are poorly understood. Here we demonstrate that occludin
phosphorylation and ubiquitination regulate VEGF-induced TJ protein trafficking and
concomitant vascular permeability. VEGF treatment induced TJ fragmentation and occludin
trafficking from the cell border to early and late endosomes, concomitant with increased …