Seizures after open heart surgery: comparison of ε-aminocaproic acid and tranexamic acid
K Martin, J Knorr, T Breuer, R Gertler… - … of Cardiothoracic and …, 2011 - Elsevier
OBJECTIVE: Although the lysine analogs tranexamic acid (TXA) and aminocaproic acid
(EACA) are used widely for antifibrinolytic therapy in cardiac surgery, relatively little research
has been performed on their safety profiles, especially in the setting of cardiac surgery. Two
antifibrinolytic protocols using either TXA or aminocaproic acid were compared according to
postoperative outcome. DESIGN: A retrospective analysis. SETTING: A university-affiliated
hospital. PARTICIPANTS: Six hundred four patients undergoing cardiac surgery …
(EACA) are used widely for antifibrinolytic therapy in cardiac surgery, relatively little research
has been performed on their safety profiles, especially in the setting of cardiac surgery. Two
antifibrinolytic protocols using either TXA or aminocaproic acid were compared according to
postoperative outcome. DESIGN: A retrospective analysis. SETTING: A university-affiliated
hospital. PARTICIPANTS: Six hundred four patients undergoing cardiac surgery …