Apoptotic cells at the crossroads of tolerance and immunity

M Škoberne, AS Beignon, M Larsson… - Role of Apoptosis in …, 2005 - Springer
M Škoberne, AS Beignon, M Larsson, N Bhardwaj
Role of Apoptosis in Infection, 2005Springer
Clearance of apoptotic cells by phagocytes can result in either anti-inflammatory and
immunosuppressive effects or prostimulatory consequences through presentation of cell-
associated antigens to T cells. The differences in outcome are due to the conditions under
which apoptosis is induced, the type of phagocytic cell, the nature of the receptors involved
in apoptotic cell capture, and the milieu in which phagocytosis of apoptotic cells takes place.
Preferential ligation of specific receptors on professional antigen-presenting cells dendriticc …
Abstract
Clearance of apoptotic cells by phagocytes can result in either anti-inflammatory and immunosuppressive effects or prostimulatory consequences through presentation of cell-associated antigens to T cells. The differences in outcome are due to the conditions under which apoptosis is induced, the type of phagocytic cell, the nature of the receptors involved in apoptotic cell capture, and the milieu in which phagocytosis of apoptotic cells takes place. Preferential ligation of specific receptors on professional antigen-presenting cells dendriticc cells) has been proposed to induce potentially tolerogenic signals. On the other hand, dendritic cells can efficiently process and present antigens from pathogen-infected apoptotic cells to T cells. In this review, we discuss how apoptotic cells manipulate immunity through interactions with dendritic cells.
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