[HTML][HTML] RNA CUG-binding protein 1 increases translation of 20-kDa isoform of CCAAT/enhancer-binding protein β by interacting with the α and β subunits of …
NA Timchenko, GL Wang, LT Timchenko - Journal of Biological Chemistry, 2005 - ASBMB
Expression of a dominant negative 20-kDa isoform of CCAAT/enhancer-binding protein
(C/EBPβ), LIP, is increased in proliferating livers and in tumor cells. Two RNA-binding
proteins, CUGBP1 and calreticulin, have been implicated in the translational regulation of
C/EBPβ. In this paper, we present evidence showing several critical steps by which liver
increases translation of LIP after partial hepatectomy. At early stages after partial
hepatectomy, liver activates CUGBP1 by a hyperphosphorylation. The activated CUGBP1 …
(C/EBPβ), LIP, is increased in proliferating livers and in tumor cells. Two RNA-binding
proteins, CUGBP1 and calreticulin, have been implicated in the translational regulation of
C/EBPβ. In this paper, we present evidence showing several critical steps by which liver
increases translation of LIP after partial hepatectomy. At early stages after partial
hepatectomy, liver activates CUGBP1 by a hyperphosphorylation. The activated CUGBP1 …