The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion
DE Levy, A Garcı́a-Sastre - Cytokine & growth factor reviews, 2001 - Elsevier
Response to IFN involves a rapid and direct signal transduction mechanism that quickly
reports that presence of extracellular cytokine to the cell nucleus, preserving the specificity
inherent in cytokine-receptor interactions to transcriptionally induce expression of a set of
genes encoding important antiviral proteins. Establishment of the resulting antiviral state
provides a crucial initial line of defense against viral infection. Studies of IFN-deficient cells
and animals derived by gene targeting have demonstrated the essential nature of IFN …
reports that presence of extracellular cytokine to the cell nucleus, preserving the specificity
inherent in cytokine-receptor interactions to transcriptionally induce expression of a set of
genes encoding important antiviral proteins. Establishment of the resulting antiviral state
provides a crucial initial line of defense against viral infection. Studies of IFN-deficient cells
and animals derived by gene targeting have demonstrated the essential nature of IFN …