[HTML][HTML] The interferon stimulated gene 54 promotes apoptosis

M Stawowczyk, S Van Scoy, KP Kumar… - Journal of biological …, 2011 - ASBMB
The ability of interferons (IFNs) to inhibit viral replication and cellular proliferation is well
established, but the specific contribution of each IFN-stimulated gene (ISG) to these
biological responses remains to be completely understood. In this report we demonstrate
that ISG54, also known as IFN-induced protein with tetratricopeptide repeats 2 (IFIT2), is a
mediator of apoptosis. Expression of ISG54, independent of IFN stimulation, elicits apoptotic
cell death. Cell death and apoptosis were quantified by propidium iodide uptake and …