Transfer of allogeneic CD62L memory T cells without graft-versus-host disease

BJ Chen, X Cui, GD Sempowski, C Liu, NJ Chao - Blood, 2004 - ashpublications.org
BJ Chen, X Cui, GD Sempowski, C Liu, NJ Chao
Blood, 2004ashpublications.org
The major challenge in allogeneic hematopoietic cell transplantation is how to transfer
allogeneic T-cell immunity without causing graft-versus-host disease (GVHD). Here we
report a novel strategy to selectively prevent GVHD by depleting CD62L+ T cells (naive and
a subset of memory T cells). In unprimed mice, CD62L–T cells (a subset of memory T cells)
failed to proliferate in response to alloantigens (which the mice have never previously
encountered) and were unable to induce GVHD in allogeneic hosts. CD62L–T cells …
Abstract
The major challenge in allogeneic hematopoietic cell transplantation is how to transfer allogeneic T-cell immunity without causing graft-versus-host disease (GVHD). Here we report a novel strategy to selectively prevent GVHD by depleting CD62L+ T cells (naive and a subset of memory T cells). In unprimed mice, CD62L T cells (a subset of memory T cells) failed to proliferate in response to alloantigens (which the mice have never previously encountered) and were unable to induce GVHD in allogeneic hosts. CD62L T cells contributed to T-cell reconstitution by peripheral expansion as well as by promoting T-cell regeneration from bone marrow stem/progenitor cells. CD62L T cells from the animals previously primed with a tumor cell line (BCL1) were able to inhibit the tumor growth in vivo but were unable to induce GVHD in the third-party recipients. This novel technology may allow transfer of allogeneic recall antitumor and antimicrobial immunity without causing GVHD.
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