Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death
J Ichikawa, D Tsuchimoto, S Oka, M Ohno, M Furuichi… - DNA repair, 2008 - Elsevier
Human MutT homolog (hMTH1) hydrolyzes oxidized purine nucleoside triphosphates to
monophosphates, thereby avoiding incorporation of such oxidized purines into DNA or RNA.
We examined whether hMTH1 prevents cellular dysfunction induced by sodium
nitroprusside, a spontaneous NO donor. Exposure to sodium nitroprusside caused an 8-
oxoguanine (8-oxoG) buildup in DNA of proliferating MTH1-null cells which underwent
mitochondrial degeneration and subsequently died. Quiescent MTH1-null cells also died …
monophosphates, thereby avoiding incorporation of such oxidized purines into DNA or RNA.
We examined whether hMTH1 prevents cellular dysfunction induced by sodium
nitroprusside, a spontaneous NO donor. Exposure to sodium nitroprusside caused an 8-
oxoguanine (8-oxoG) buildup in DNA of proliferating MTH1-null cells which underwent
mitochondrial degeneration and subsequently died. Quiescent MTH1-null cells also died …