[HTML][HTML] A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes
Striatin and S/G 2 nuclear autoantigen (SG2NA) are related proteins that contain membrane
binding domains and associate with protein phosphatase 2A (PP2A) and many additional
proteins that may be PP2A regulatory targets. Here we identify a major member of these
complexes as class II mMOB1, a mammalian homolog of the yeast protein MOB1, and show
that its phosphorylation appears to be regulated by PP2A. Yeast MOB1 is critical for
cytoskeletal reorganization during cytokinesis and exit from mitosis. We show that mMOB1 …
binding domains and associate with protein phosphatase 2A (PP2A) and many additional
proteins that may be PP2A regulatory targets. Here we identify a major member of these
complexes as class II mMOB1, a mammalian homolog of the yeast protein MOB1, and show
that its phosphorylation appears to be regulated by PP2A. Yeast MOB1 is critical for
cytoskeletal reorganization during cytokinesis and exit from mitosis. We show that mMOB1 …