[HTML][HTML] Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia [S]
W Yin, E Carballo-Jane, DG McLaren… - Journal of lipid …, 2012 - ASBMB
In an attempt to understand the applicability of various animal models to dyslipidemia in
humans and to identify improved preclinical models for target discovery and validation for
dyslipidemia, we measured comprehensive plasma lipid profiles in 24 models. These
included five mouse strains, six other nonprimate species, and four nonhuman primate
(NHP) species, and both healthy animals and animals with metabolic disorders.
Dyslipidemic humans were assessed by the same measures. Plasma lipoprotein profiles …
humans and to identify improved preclinical models for target discovery and validation for
dyslipidemia, we measured comprehensive plasma lipid profiles in 24 models. These
included five mouse strains, six other nonprimate species, and four nonhuman primate
(NHP) species, and both healthy animals and animals with metabolic disorders.
Dyslipidemic humans were assessed by the same measures. Plasma lipoprotein profiles …