Involvement of a cGMP-dependent pathway in the natriuretic peptide-mediated hormone-sensitive lipase phosphorylation in human adipocytes
C Sengenes, A Bouloumié, H Hauner, M Berlan… - Journal of Biological …, 2003 - ASBMB
Our previous studies have demonstrated that natriuretic peptides (NPs), peptide hormones
with natriuretic, diuretic, and vasodilating properties, exert a potent control on the lipolysis in
human adipocytes via the activation of the type A guanylyl cyclase receptor (1, 2). In the
current study we investigated the intracellular mechanisms involved in the NP-stimulated
lipolytic effect in human preadipocytes and adipocytes. We demonstrate that the atrial NP
(ANP)-induced lipolysis in human adipocytes was associated with an enhanced serine …
with natriuretic, diuretic, and vasodilating properties, exert a potent control on the lipolysis in
human adipocytes via the activation of the type A guanylyl cyclase receptor (1, 2). In the
current study we investigated the intracellular mechanisms involved in the NP-stimulated
lipolytic effect in human preadipocytes and adipocytes. We demonstrate that the atrial NP
(ANP)-induced lipolysis in human adipocytes was associated with an enhanced serine …
