Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis
C El-Aouni, N Herbach, SM Blattner… - Journal of the …, 2006 - journals.lww.com
Alterations in glomerular podocyte cell–cell and cell–matrix contacts are key events in
progressive glomerular failure. Integrin-linked kinase (ILK) has been implicated in podocyte
cell–matrix interaction and is induced in proteinuria. For evaluation of ILK function in vivo,
mice with a Cre-mediated podocyte-specific ILK inactivation were generated. These mice
seemed normal at birth but developed progressive focal segmental glomerulosclerosis and
died in terminal renal failure. The first ultrastructural lesions that are seen at onset of …
progressive glomerular failure. Integrin-linked kinase (ILK) has been implicated in podocyte
cell–matrix interaction and is induced in proteinuria. For evaluation of ILK function in vivo,
mice with a Cre-mediated podocyte-specific ILK inactivation were generated. These mice
seemed normal at birth but developed progressive focal segmental glomerulosclerosis and
died in terminal renal failure. The first ultrastructural lesions that are seen at onset of …