[HTML][HTML] Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells

A Alberghini, S Recalcati, L Tacchini… - Journal of Biological …, 2005 - ASBMB
Given the modulation of iron metabolism by hypoxia and the high iron requirement of
neoplastic cells, we investigated iron metabolism in a human renal cancer cell line with a
mutated von Hippel Lindau (VHL) tumor suppressor gene (RCC10) and in a transfectant
clone with wild-type VHL (RCC63). The loss of VHL strongly up-regulated transferrin
receptor expression in RCC10 cells as a result of hypoxia inducible factor-1 (HIF-1)-
mediated transcriptional activation, leading to an increased uptake of transferrin-bound 55 …