Long non-coding RNAs: insights into functions
Nature reviews genetics, 2009•nature.com
In mammals and other eukaryotes most of the genome is transcribed in a developmentally
regulated manner to produce large numbers of long non-coding RNAs (ncRNAs). Here we
review the rapidly advancing field of long ncRNAs, describing their conservation, their
organization in the genome and their roles in gene regulation. We also consider the medical
implications, and the emerging recognition that any transcript, regardless of coding potential,
can have an intrinsic function as an RNA.
regulated manner to produce large numbers of long non-coding RNAs (ncRNAs). Here we
review the rapidly advancing field of long ncRNAs, describing their conservation, their
organization in the genome and their roles in gene regulation. We also consider the medical
implications, and the emerging recognition that any transcript, regardless of coding potential,
can have an intrinsic function as an RNA.
Abstract
In mammals and other eukaryotes most of the genome is transcribed in a developmentally regulated manner to produce large numbers of long non-coding RNAs (ncRNAs). Here we review the rapidly advancing field of long ncRNAs, describing their conservation, their organization in the genome and their roles in gene regulation. We also consider the medical implications, and the emerging recognition that any transcript, regardless of coding potential, can have an intrinsic function as an RNA.
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