[HTML][HTML] The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
P Krishnamurthy, DD Ross, T Nakanishi… - Journal of Biological …, 2004 - ASBMB
Our studies demonstrate that the ABC transporter and marker of stem and progenitor cells
known as the breast cancer resistance protein (BCRP or ABCG2) confers a strong survival
advantage under hypoxic conditions. We show that, under hypoxia, progenitor cells from
Bcrp–/–mice have a reduced ability to form colonies as compared with progenitor cells from
Bcrp+/+ mice. Blocking BCRP function in Bcrp+/+ progenitor cells markedly reduces survival
under hypoxic conditions. However, blocking heme biosynthesis reverses the hypoxic …
known as the breast cancer resistance protein (BCRP or ABCG2) confers a strong survival
advantage under hypoxic conditions. We show that, under hypoxia, progenitor cells from
Bcrp–/–mice have a reduced ability to form colonies as compared with progenitor cells from
Bcrp+/+ mice. Blocking BCRP function in Bcrp+/+ progenitor cells markedly reduces survival
under hypoxic conditions. However, blocking heme biosynthesis reverses the hypoxic …