The influence of environmental and genetic factors on behavior problems and autistic symptoms in boys and girls with fragile X syndrome

D Hessl, J Dyer-Friedman, B Glaser, J Wisbeck… - …, 2001 - publications.aap.org
Objective. Fragile X syndrome, caused by mutations in a single gene of the X chromosome
(FMR1), is associated with neurobehavioral characteristics including social deficits with
peers, social withdrawal, gaze aversion, inattention, hyperactivity, anxiety, depression, and
autistic behavior. However, there is considerable variability in the behavioral and psychiatric
problems among children with this condition. The purpose of this study was to measure
genetic and environmental factors influencing behavior problems and autistic symptoms in …