[HTML][HTML] Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase C-γ1
Y Harita, H Kurihara, H Kosako, T Tezuka… - Journal of biological …, 2009 - ASBMB
A specialized intercellular junction between podocytes, known as the slit diaphragm (SD),
forms the essential structural frame-work for glomerular filtration in the kidney. In addition,
mounting evidence demonstrates that the SD also plays a crucial role as a signaling
platform in physiological and pathological states. Nephrin, the major component of the SD, is
tyrosine-phosphorylated by a Src family tyrosine kinase, Fyn, in developing or injured
podocytes, recruiting Nck to Nephrin via its Src homology 2 domain to regulate dynamic …
forms the essential structural frame-work for glomerular filtration in the kidney. In addition,
mounting evidence demonstrates that the SD also plays a crucial role as a signaling
platform in physiological and pathological states. Nephrin, the major component of the SD, is
tyrosine-phosphorylated by a Src family tyrosine kinase, Fyn, in developing or injured
podocytes, recruiting Nck to Nephrin via its Src homology 2 domain to regulate dynamic …