[HTML][HTML] SH2-B, a membrane-associated adapter, is phosphorylated on multiple serines/threonines in response to nerve growth factor by kinases within the MEK/ERK …
L Rui, J Herrington, C Carter-Su - Journal of Biological Chemistry, 1999 - ASBMB
SH2-B has been shown to be required for nerve growth factor (NGF)-mediated neuronal
differentiation and survival, associate with NGF receptor TrkA, and be tyrosyl-
phosphorylated in response to NGF. In this work, we examined whether NGF stimulates
phosphorylation of SH2-B on serines/threonines. NGF promotes a dramatic upward shift in
mobility of SH2-B, resulting in multiple forms that cannot be attributed to tyrosyl
phosphorylation. Treatment of SH2-B with protein phosphatase 2A, a serine/threonine …
differentiation and survival, associate with NGF receptor TrkA, and be tyrosyl-
phosphorylated in response to NGF. In this work, we examined whether NGF stimulates
phosphorylation of SH2-B on serines/threonines. NGF promotes a dramatic upward shift in
mobility of SH2-B, resulting in multiple forms that cannot be attributed to tyrosyl
phosphorylation. Treatment of SH2-B with protein phosphatase 2A, a serine/threonine …